Clinical Study 2
OBJECTIVE:
Comparison of epidermal cell proliferation produced by SESHA SKIN THERAPY A.C.E. Cream containing PET™ nutrient delivery system with Retin-A Cream (0.025%) and Oil of Olay Original Beauty Fluid.
PROTOCOL AND STUDY PARAMETERS:
7-day in-vivo study
RESULTS:
The A.C.E Cream significantly thickened the epidermis. The skin is plump and has characteristics of young, healthy skin.
Retin-A 0.025% produced a slight increase of skin cells, but the epidermis is damaged.
Oil of Olay did not show signs of cell proliferation.
CONCLUSION:
Biopsies stained with hematoxylin and eosin at 400x magnification show that A.C.E. Cream is an effective stimulator of epidermal cells.
Study conducted by Peter T. Pugliese, M.D.
Table #1 – Epidermal Thickness in microns (micrometers):
| SUBJECT | A.C.E . CREAM | RETIN-A 0.025% | OIL OF OLAY |
| A | 50.3 | 33 | 19.8 |
| B | 47.3 | 34 | 21 |
| C | 59.5 | 39 | 18 |
| D | 58.3 | 39 | 21 |
| E | 51.5 | 36 | 21 |
| MEAN | 53.4 | 36.2 | 20.2 |
Hematoxylin and Eosin Stain of sample skin biopsies at 400x :
