Clinical Skincare that Delivers Results

Science-Based Formulations

Clinically inspired skincare backed by 30+ years of expertise.

P.E.T.® Delivery Technology

Proprietary technology designed to enhance ingredient absorption.

Professional Clinical Grade

Trusted by Skincare Professionals Worldwide

Ethical & Accessible

U.S. research and non-animal testing.

 

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PD-RN REGENERATIVE SERUM

Specially derived from a compound called polydeoxyribonucleotide (PD-RN), this compound triggers cellular activity near the source of application to deliver lasting rejuvenation and health of the skin.

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Professional-grade P.E.T. skincare technology graphic by Sesha, showcasing advanced science-based solutions.

P.E.T.® Technology Delivery

P.E.T.® allows the penetration of anti-aging ingredients to the regenerative layer of the epidermis, where new cells are created. When new cells are fed and nourished with antioxidants, peptides, and other active ingredients, the skin will not only look and feel healthier, it will truly be healthier.

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What our community is raving about

Hear from our clients and customers to see what helps them achieve their best skin!

SESHA® Features

Over 30 years of skincare innovation

Our Story

Born from a biomedical breakthrough, SESHA Skin Therapy was founded by Harvard- and MIT-educated scientist Dr. Dean Hsieh, whose discovery of Permeation Enhancement Technology (P.E.T.®)  helped advance ingredient delivery through the skin—technology later used in an FDA-approved pharmaceutical product (2002). During early testing, researchers uncovered something remarkable: P.E.T.® could also help prevent and restore visible skin damage by helping key actives reach where they matter most.

Since launching our first products in 1996—SESHA has continued to expand into a complete line of science-based, results-driven skincare with anti-aging solutions for every skin type and every age.

In 1996, from the idea that our skin’s aging process can be significantly slowed if active ingredients are allowed to penetrate and feed our regenerative living cells, SESHA SKIN THERAPY’s first two products were born – the A.C.E. Cream and A.C.E. Emulsion. Since then, SESHA SKIN THERAPY has extended and expanded it’s anti-aging line to include levels of treatment for all types of skin and for all ages.