Understanding PDRN: Professional Skin Regeneration—In the Treatment Room and at Home

In advanced professional skincare and aesthetic medicine, PDRN (Polydeoxyribonucleotide) has become one of the most powerful regenerative ingredients available today—and for good reason. Originally studied and used in medical wound healing, dermatology, and regenerative therapies, PDRN is now widely recognized in esthetic and clinical skincare for its ability to support cellular renewal, skin barrier repair, inflammation control, and long-term skin health. At SESHA Skin Therapy, we formulate PDRN to pharmaceutical-grade standards and combine it with our proprietary Permeation Enhancement Technology (P.E.T.®) to ensure optimal bioavailability and deep skin delivery, whether used in professional treatment settings or as part of a home-care maintenance routine. To support both in-office results and client at-home continuation, SESHA has developed two specialized PDRN formulations, each designed to play a distinct role in the skin regeneration process.

What Is PDRN and Why Professionals Use It

PDRN is derived from highly purified salmon DNA fragments that closely resemble human DNA structures. Once applied to the skin, PDRN activates the A2A adenosine receptor pathway, triggering biological repair mechanisms that help the skin restore itself from within. Clinically, PDRN has been shown to:

• Support cellular repair and regeneration
• Improve wound healing and tissue recovery
• Strengthen the skin barrier
• Reduce inflammation and sensitivity
• Promote collagen and elastin synthesis
• Enhance overall skin resilience and vitality

Rather than functioning as a temporary cosmetic solution, PDRN improves the biological environment of the skin, making it ideal for:

• Post-procedure recovery
• Aging or compromised skin
• Sensitive or inflamed skin conditions
• Barrier-impaired or trauma-exposed skin

This is why esthetic professionals, medical spas, nurses, nurse practitioners, and physician-led practices increasingly rely on PDRN for both clinical treatments and maintenance protocols.

Why SESHA Created Two Different PDRN Formulas

Professional skin treatments and daily home care require very different formulations, viscosities, and delivery systems. That is why SESHA developed:

1. PDRN Booster — for professional nano-infusion treatments

2. PDRN Regenerative Serum — for client home care and long-term skin repair

Using both correctly allows practitioners to:

• Maximize treatment-room results
• Improve client recovery and comfort
• Increase retail compliance
• Deliver long-term regenerative outcomes

PDRN Booster

Professional Use Only | Nano-Infusion Formula The PDRN Booster is a high-strength, professional-grade regenerative serum designed specifically for use with nano-infusion devices, including the MesoBotanica Nano Pen.

What Makes It Different:

• Optimized viscosity for nano-channel penetration
• Designed for deep infusion into the epidermis

Works synergistically with mechanical nano-stimulation

• Delivers intensive regenerative support without irritation

When to Use:

• During nano-infusion or mesotherapy-style treatments
• In post-procedure regeneration protocols
• For advanced anti-aging, scarring, or barrier repair

Important:

This product is intended for licensed skincare and healthcare professionals only. It 
is not formulated for consumer retail or unsupervised home use.

PDRN Regenerative Serum

Home Care & Post-Treatment Maintenance: The PDRN Regenerative Serum brings the benefits of PDRN into a daily skincare format so clients can extend and protect the results achieved in the treatment room.

Why It’s Ideal for Home Use:

• Gentle, skin-friendly formula for daily application
• Supports cellular renewal and barrier recovery
• Helps calm redness, irritation, and inflammation
• Safe for long-term use on all skin types When to Recommend
• After professional procedures
• As a daily anti-aging or recovery serum
• For sensitive, compromised, or post-treatment skin

How Professionals Should Position PDRN: Think of PDRN as a two-step professional system:

• PDRN Booster activates regeneration during the treatment
• PDRN Regenerative Serum maintains and builds results at home

This strategy delivers:

• Faster visible improvement
• Better client satisfaction
• Higher retail compliance
• Stronger long-term outcomes

We use a professional-strength PDRN during your treatment to activate deep skin regeneration. Then this serum continues that repair process safely every day—so your skin keeps improving between visits.

In Summary