Study 2

OBJECTIVE:

Comparison of epidermal cell proliferation produced by SESHA SKIN THERAPY A.C.E. Cream containing PET™  delivery system with Retin-A Cream (0.025%) and Oil of Olay Original Beauty Fluid.

PROTOCOL AND STUDY PARAMETERS:

7-day in-vivo study

RESULTS:

  • The A.C.E Cream significantly thickened the epidermis. The skin is plump and has characteristics of young, healthy skin.
  • Retin-A 0.025% produced a slight increase of skin cells, but the epidermis is damaged.
  • Oil of Olay did not show signs of cell proliferation.

CONCLUSION:

Biopsies stained with hematoxylin and eosin at 400x magnification show that A.C.E. Cream is an effective stimulator of epidermal cells.
Study conducted by Peter T. Pugliese, M.D.

Table #1 – Epidermal Thickness in microns (micrometers):

SUBJECT A.C.E. CREAM RETIN-A 0.025% OIL OF OLAY
A
B
C
D
E
50.3
47.3
59.5
58.3
51.5
33
34
39
39
36
19.8
21
18
21
21
MEAN 53.4 36.2 20.2

Hematoxylin and Eosin Stain of sample skin biopsies at 400x :